1-phosphatidylinositol-5-phosphate 4-kinase

Class of enzymes 1-phosphatidylinositol-5-phosphate 4-kinase 2.7.1.149 0016309 In enzymology, a 1-phosphatidylinositol-5-phosphate 4-kinase (2.7.1.149) is an enzyme that catalyzes the chemical reaction ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 5-phosphate, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase. This enzyme is also called type II PIP kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and regulation of actin cytoskeleton. References 1 Rameh LE, Tolias KF, Duckworth BC, Cantley LC 1997 A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate Nature 390 192–6 9367159 10.1038/36621 6656 1997Natur.390..192R Biology no Category:EC 2.7.1 Category:Enzymes of unknown structure