11-cis-retinol dehydrogenase

Class of enzymes 11-cis-retinol dehydrogenase 1.1.1.315 11-cis-retinol dehydrogenase (1.1.1.315, RDH5 (gene)) is an enzyme with systematic name 11-cis-retinol:NAD+ oxidoreductase. Simon A, Hellman U, Wernstedt C, Eriksson U The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases The Journal of Biological Chemistry 270 3 1107–12 January 1995 7836368 10.1074/jbc.270.3.1107 free Wang J, Chai X, Eriksson U, Napoli JL Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue The Biochemical Journal 338 23–7 February 1999 Pt 1 9931293 1220019 10.1042/0264-6021:3380023 Lidén M, Romert A, Tryggvason K, Persson B, Eriksson U Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus The Journal of Biological Chemistry 276 52 49251–7 December 2001 11675386 10.1074/jbc.M107337200 free Wu Z, Yang Y, Shaw N, Bhattacharya S, Yan L, West K, Roth K, Noy N, Qin J, Crabb JW Mapping the ligand binding pocket in the cellular retinaldehyde binding protein The Journal of Biological Chemistry 278 14 12390–6 April 2003 12536149 10.1074/jbc.M212775200 free This enzyme catalyses the following chemical reaction 11-cis-retinol---[retinal-binding-protein] + NAD+ 11-cis-retinal---[retinol-binding-protein] + NADH + H+ thumb|11-cis-retinol This enzyme from retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal. References External links 11-cis-retinol+dehydrogenase Biology no Category:EC 1.1.1