(S)-iPr-PHOX

(S)-iPr-PHOX (S)-iPr-PHOX.svg (4S)-2-[2-(Diphenylphosphanyl)phenyl]-4-(propan-2-yl)-4,5-dihydro-1,3-oxazole 148461-14-7 correct FDA 9BR74U8QLZ 9807779 7983538 CC(C)[C@H]1COC(=N1)C2=CC=CC=C2P(C3=CC=CC=C3)C4=CC=CC=C4 1S/C24H24NOP/c1-18(2)22-17-26-24(25-22)21-15-9-10-16-23(21)27(19-11-5-3-6-12-19)20-13-7-4-8-14-20/h3-16,18,22H,17H2,1-2H3/t22-/m1/s1 OUQSAXROROGQEE-JOCHJYFZSA-N 24 24 1 1 1 White solid 85 to 90 (S)-iPr-PHOX, or (S)-2-[2-(diphenylphosphino)phenyl]-4-isopropyl-4,5-dihydrooxazole, is a chiral, bidentate, ligand derived from the amino alcohol valinol. It is part of a broader class of phosphinooxazolines ligands and has found application in asymmetric catalysis. Preparation (S)-iPr-PHOX is prepared using the amino alcohol valinol, which is derived from valine. The phosphine moiety may be introduced first, by a reaction between 2-bromobenzonitrile and chlorodiphenylphosphine; the oxazoline ring is then formed in a Witte Seeliger reaction. This yields an air stable zinc complex which must be treated with bipyridine in order to obtain the free ligand. Synthesis is performed under argon or nitrogen to avoid contact with air, however the final product is not air sensitive. 650px Uses Iridium complexes incorporating (S)-iPr-PHOX have been used for asymmetric hydrogenation. 10.1007/978-3-642-15334-1_3 Iridium-Catalyzed Asymmetric Hydrogenation of Olefins with Chiral N,P and C,N Ligands Iridium Catalysis Topics in Organometallic Chemistry 2011 Woodmansee David H. Pfaltz Andreas 978-3-642-15333-4 34 31 https://zenodo.org/record/1230507 References Category:Ligands Category:Phosphines Category:Oxazolines