2-hydroxypropyl-CoM lyase

Class of enzymes 2-hydroxypropyl-CoM lyase 4.4.1.23 244301-07-3 The enzyme 2-hydroxypropyl-CoM lyase (EC 4.4.1.23, epoxyalkane:coenzyme M transferase, epoxyalkane:CoM transferase, epoxyalkane:2-mercaptoethanesulfonate transferase, coenzyme M-epoxyalkane ligase, epoxyalkyl:CoM transferase, epoxypropane:coenzyme M transferase, epoxypropyl:CoM transferase, EaCoMT, 2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming), (R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing, (R)-1,2-epoxypropane-forming)) is an enzyme with systematic name (R)-[or (S)]-2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming). Allen JR, Clark DD, Krum JG, Ensign SA A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation Proceedings of the National Academy of Sciences of the United States of America 96 15 8432–7 July 1999 10411892 17533 10.1073/pnas.96.15.8432 1999PNAS...96.8432A free Krum JG, Ellsworth H, Sargeant RR, Rich G, Ensign SA Kinetic and microcalorimetric analysis of substrate and cofactor interactions in epoxyalkane:CoM transferase, a zinc-dependent epoxidase Biochemistry 41 15 5005–14 April 2002 11939797 10.1021/bi0255221 Coleman NV, Spain JC Epoxyalkane: coenzyme M transferase in the ethene and vinyl chloride biodegradation pathways of mycobacterium strain JS60 Journal of Bacteriology 185 18 5536–45 September 2003 12949106 193758 10.1128/jb.185.18.5536-5545.2003 This enzyme catalyses the following reaction: (1) (R)-2-hydroxypropyl-CoM (R)-1,2-epoxypropane + HS-CoM (2) (S)-2-hydroxypropyl-CoM (S)-1,2-epoxypropane + HS-CoM This enzyme requires zinc. References External links 2-hydroxypropyl-CoM+lyase Biology no Category:EC 4.4.1