2,6-Dichloromescaline

vanc 6 2,6-Dichloromescaline.svg skin-invert-image Serotonin receptor modulator; Serotonergic psychedelic; Hallucinogen None 2,6-CM; Dichloromescaline; DCL-M; DCl-M; 2,6-Dichloro-3,4,5-trimethoxyphenethylamine 2-(2,6-dichloro-3,4,5-trimethoxyphenyl)ethan-1-amine 11 15 2 1 3 NCCc1c(Cl)c(OC)c(c(c1Cl)OC)OC 1S/C11H15Cl2NO3/c1-15-9-7(12)6(4-5-14)8(13)10(16-2)11(9)17-3/h4-5,14H2,1-3H3 KXHHCBHONMZNGQ-UHFFFAOYSA-N 2,6-Dichloromescaline (2,6-CM), or dichloromescaline (DCL-M, DCM), also known as 2,6-dichloro-3,4,5-trimethoxyphenethylamine, is a psychedelic drug of the scaline family related to mescaline. Trachsel D, Lehmann D, Enzensperger C Phenethylamine: von der Struktur zur Funktion Solothurn 935–936 2013 Phenethylamines: From Structure to Function 1st Nachtschatten-Verlag Nachtschatten-Science 978-3-03788-700-4 858805226 https://books.google.com/books?id=-Us1kgEACAAJ de https://web.archive.org/web/20251113135159/https://books.google.com/books?id=-Us1kgEACAAJ 13 November 2025 25 November 2025 bot: unknown Shulgin A, Manning T, Daley P The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds Berkeley 1 2011 Transform Press 978-0-9630096-3-0 (1) 2-CM was an artifact in the isolation of mescaline from Trichocereus peruvianus; 2,6-CM is synthetic (Pardanani et al., 1977). 2,6-CM (Dicloromescaline) 1 May 1998 АИПСИН https://aipsin.com/newsubstance/253/ ru 25 November 2025 It is the 2,6-dichloro derivative of mescaline and the 6-chloro derivative of 2-chloromescaline. Interactions Psychedelic drug#Interactions Trip killer#Serotonergic psychedelic antidotes Pharmacology Pharmacodynamics The drug shows affinity for serotonin receptors, including the serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors (Ki = 86nM, 659nM, and 801nM, respectively). These affinities were 35-fold, 7-fold, and 10-fold higher than those of mescaline, respectively. History 2,6-Dichloromescaline was first described in the scientific literature by 1977. Pardanani JH, McLaughlin JL, Kondrat RW, Cooks RG Cactus alkaloids. XXXVI. Mescaline and related compounds from Trichocereus peruvianus Lloydia 40 6 585–590 1977 600028 Its serotonin receptor affinities were determined by David E. Nichols and colleagues, with subsequent disclosure by Daniel Trachsel and colleagues via personal communication in 2013. 2,6-Dichloromescaline has been encountered as a novel designer drug and is said to have been on the recreational market since at least the 1990s. Relatedly, the properties and effects of 2,6-dichloromescaline in humans were described in The Entheogen Review in 1997, claiming a dose of approximately 10mg orally to be robustly active. Inner Frontiersman First Known Human Voyage on DCM -- 2,6-Dichloromescaline The Entheogen Review 6 1 12–13 1997 1066-1913 https://archive.org/details/TheEntheogenReviewComplete19922008/page/n358/mode/2up However, a subsequent investigation concluded that this report was fabricated.The Inner Frontiersman and Toad Dichloromescaline Erowid https://www.erowid.org/archive/rhodium/chemistry/dichloromescaline.html 30 March 2026 Society and culture Legal status Canada 2,6-Dichloromescaline is not a controlled substance in Canada as of 2025.Controlled Drugs and Substances Act Department of Justice Canada https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 19 January 2026 See also Scaline 2-Chloromescaline 2,6-Dibromomescaline 2,6-Dimethylmescaline References External links 2,6-Dichloromescaline - Isomer Design 2,6-Dichloromescaline - Trout's Notes Dichloromescaline - Toad - Rhodium Site Archive - Erowid Eugenoloids: C-POMA; 2-Chloro-4-propoxy-5-methoxyamphetamine - Demonic - Isomer Design Hallucinogens You Probably Haven't Heard of: Halogenated Mescaline Analogues - Nervewing - Blogger Category:Chlorobenzenes Category:Designer drugs Category:Scalines Category:Serotonin receptor modulators