(−)-germacrene D synthase

Class of enzymes (−)-germacrene D synthase 4.2.3.75 (−)-Germacrene D synthase (EC 4.2.3.75) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((−)-germacrene-D-forming). Schmidt CO, Bouwmeester HJ, Franke S, König WA Mechanisms of the biosynthesis of sesquiterpene enantiomers (+)- and (−)-germacrene D in Solidago canadensis Chirality 1999 11 5–6 353–362 10.1002/(sici)1520-636x(1999)11:5/6<353::aid-chir2>3.0.co;2-l He X, Cane DE Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2) Journal of the American Chemical Society 126 9 2678–9 March 2004 14995166 10.1021/ja039929k 2004JAChS.126.2678H Lücker J, Bowen P, Bohlmann J Vitis vinifera terpenoid cyclases: functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (−)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries Phytochemistry 65 19 2649–59 October 2004 15464152 10.1016/j.phytochem.2004.08.017 Prosser I, Altug IG, Phillips AL, König WA, Bouwmeester HJ, Beale MH Enantiospecific (+)- and (−)-germacrene D synthases, cloned from goldenrod, reveal a functionally active variant of the universal isoprenoid-biosynthesis aspartate-rich motif Archives of Biochemistry and Biophysics 432 2 136–44 December 2004 15542052 10.1016/j.abb.2004.06.030 This enzyme catalyses the following chemical reaction (2E,6E)-farnesyl diphosphate (−)-germacrene D + diphosphate In Solidago canadensis the biosynthesis results in the pro-R hydrogen at C-1 of the farnesyl diphosphate ending up at C-11 of the (−)-germacrene D . References External links (−)-germacrene+D+synthase Biology no Category:EC 4.2.3