2,2'-Azobis(2-amidinopropane) dihydrochloride

2,2'-Azobis(2-amidinopropane) dihydrochloride.svg (1Z,1'Z)-2,2'-[(E)-1,2-Diazenediyl]bis(2-methylpropanimidamide) dihydrochloride AAPH; AMPA; 2,2'-Azobisisobutyramidinium chloride 2997-92-4 correct CAS correct FDA 7381JDR72F 68821 84924 Cl.Cl.[N@H]=C(N)C(/N=N/C(C(=[N@H])N)(C)C)(C)C 1S/C8H18N6.2ClH/c1-7(2,5(9)10)13-14-8(3,4)6(11)12;;/h1-4H3,(H3,9,10)(H3,11,12);2*1H/b14-13+ LXEKPEMOWBOYRF-QDBORUFSSA-N 8 20 2 6 2,2'-Azobis(2-amidinopropane) dihydrochloride (abbreviated AAPH or AMPA) is a chemical compound used to study the chemistry of the oxidation of drugs. Betigeri S. Thakur A. Raghavan K. 10.1007/s11095-004-1199-x Use of 2,2?-Azobis(2-Amidinopropane) Dihydrochloride as a Reagent Tool for Evaluation of Oxidative Stability of Drugs Pharmaceutical Research 22 2 310–317 2005 15783080 38031845 It is a free radical-generating azo compound. It is gaining prominence as a model oxidant in small molecule and protein therapeutics for its ability to initiate oxidation reactions via both nucleophilic and free radical mechanisms. Werber J. Wang Y. J. Milligan M. Li X. Ji J. A. Analysis of 2,2′-azobis (2-amidinopropane) dihydrochloride degradation and hydrolysis in aqueous solutions 10.1002/jps.22578 Journal of Pharmaceutical Sciences 100 8 3307–3315 2011 21560126 2,2′-azobis (2-amidinopropane) dihydrochloride has been used in experiments on linoleic acid subjected to induced oxidation with different combinations of binary mixtures of natural phenolics. The experiments show that some binary mixtures can lead to a synergetic antioxidant effect while other mixtures lead to an antagonistic effect.Antioxidant activity of phenolic compounds in 2,2′-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced oxidation: Synergistic and antagonistic effects. M. N. Peyrat-Maillard, M. E. Cuvelier and C. Berset, Journal of the American Oil Chemists' Society, 2003, Volume 80, Number 10, pages 1007-1012, 10.1007/s11746-003-0812-z References Category:Azo compounds Category:Amidines Category:Hydrochlorides