(Skp1-protein)-hydroxyproline N-acetylglucosaminyltransferase

Enzyme (Skp1-protein)-hydroxyproline N-acetylglucosaminyltransferase 2.4.1.229 In enzymology, a [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase (2.4.1.229) is an enzyme that catalyzes the chemical reaction UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline Thus, the two substrates of this enzyme are UDP-N-acetylglucosamine and Skp1-protein-hydroxyproline, whereas its two products are UDP and Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline. This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:[Skp1-protein]-hydroxyproline N-acetyl-D-glucosaminyl-transferase. Other names in common use include Skp1-HyPro GlcNAc-transferase, UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide, GlcNAc-transferase, UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase, and UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase. References 1 CM 2002 Molecular cloning and expression of a UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase that modifies Skp1 in the cytoplasm of dictyostelium J. Biol. Chem. 277 46328–37 12244115 10.1074/jbc.M208024200 Morris HR Panico M Paxton T Dell A Kaplan L West CM 48 free Teng-Umnuay P, van der Wel H, West CM 1999 Identification of a UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase in the cytoplasm of Dictyostelium J. Biol. Chem. 274 36392–402 10593934 10.1074/jbc.274.51.36392 51 free West CM, van der Wel H, Gaucher EA 2002 Complex glycosylation of Skp1 in Dictyostelium: implications for the modification of other eukaryotic cytoplasmic and nuclear proteins Glycobiology 12 17R–27R 11886837 10.1093/glycob/12.2.17R 2 free Biology no Category:EC 2.4.1 Category:Enzymes of unknown structure