2-Hydroxybenzylamine

Chemical compound 2-HOBA 2-HOBA_structure.png skin-invert-image 7 9 1 1 2-(aminomethyl)phenol correct CAS 932-30-9 correct FDA 696R5N4NRM 155572 63452 70267 DB14855 C1=CC=C(C(=C1)CN)O 1S/C7H9NO/c8-5-6-3-1-2-4-7(6)9/h1-4,9H,5,8H2 KPRZOPQOBJRYSW-UHFFFAOYSA-N 2-Hydroxybenzylamine (2-HOBA, marketed as Hobamine) is a natural product found in Himalayan tartary buckwheat (Fagopyrum tataricum). It acts as an antioxidant and is thus sold as a dietary supplement.Fuller JC, Pitchford LM, Morrison RD, Daniels JS, Flynn CR, Abumrad NN, Oates JA, Boutaud O, Rathmacher JA Naji Abumrad November 2018 In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate Food and Chemical Toxicology 121 541–548 10.1016/j.fct.2018.09.047 6220894 302532456 Tao H, Huang J, Yancey PG, Yermalitsky V, Blakemore JL, Zhang Y, Ding L, Zagol-Ikapitte I, Ye F, Amarnath V, Boutaud O, Oates JA, Roberts LJ, Davies SS, Linton MF August 2020 Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr-/- mice Nature Communications 11 1 4084 2020NatCo..11.4084T 10.1038/s41467-020-17915-w free 7429830 32796843May-Zhang LS, Kirabo A, Huang J, Linton MF, Davies SS, Murray KT January 2021 Scavenging Reactive Lipids to Prevent Oxidative Injury Annual Review of Pharmacology and Toxicology 61 291–308 10.1146/annurev-pharmtox-031620-035348 32997599 222170646 free 6 O'Neill MJ, Yoneda ZT, Crawford DM, Ye F, Ao M, Pitchford LM, Rathmacher JA, Murray KT, Akers WS, Roden DM, Michaud GF, Shoemaker MB August 2021 2-Hydroxybenzylamine (2-HOBA) to prevent early recurrence of atrial fibrillation after catheter ablation: protocol for a randomized controlled trial including detection of AF using a wearable device Trials 22 1 576 10.1186/s13063-021-05553-6 8403349 34454591 free References Category:2-Hydroxyphenyl compounds