2-Hydroxysaclofen

Chemical compound, GABA(B) receptor antagonist 2-Hydroxysaclofen 2-Hydroxysaclofen.svg skin-invert-image 3-Amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid 117354-64-0 111179 1256573 1509 634-206-2 1068 1564 X5IFR0UF10 C1=CC(=CC=C1C(CN)(CS(=O)(=O)O)O)Cl 1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15) WBSMZVIMANOCNX-UHFFFAOYSA-N 9 12 1 1 4 1 2-Hydroxysaclofen is a GABAB receptor antagonist and an analogue of saclofen. Pharmacodynamics 2-Hydroxysaclofen binds to the GABAB receptor, but this is selective for the (S)-enantiomer, while the (R)-enantiomer does not bind to the GABAB protein.Froestl Wolfgang Enna S.J. XPharm: The Comprehensive Pharmacology Reference 2-Hydroxysaclofen 2007 1–6 10.1016/B978-008055232-3.61101-8 978-0-08-055232-3 2-Hydroxysaclofen has been reported to be more potent than saclofen.2-Hydroxysaclofen https://www.tocris.com/products/2-hydroxysaclofen_0245 See also Saclofen - another GABAB receptor antagonist Baclofen - an agonist of the receptor References Category:GABA receptor antagonists Category:4-Chlorophenyl compounds Category:Sulfonic acids Category:Tertiary alcohols Category:Amines Category:Ethanolamines