2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase

Class of enzymes 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase 3.5.1.102 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase (3.5.1.102, ArfB) is an enzyme with systematic name 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one amidohydrolase.3.5.1.102 It catalyses the hydrolysis of 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and formic acid, which is the second step in riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis in archaea: Grochowski LL, Xu H, White RH An iron(II) dependent formamide hydrolase catalyzes the second step in the archaeal biosynthetic pathway to riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin Biochemistry 48 19 4181–8 May 2009 19309161 10.1021/bi802341p Schomburg Dietmar Schomburg Ida Class 3.4–6 Hydrolases, Lyases, Isomerases, Ligases 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase 3.5.1.102 2013 244–246 10.1007/978-3-642-36260-6_13 978-3-642-36259-0 70% 2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one H2O HCO2H 2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1.2 The enzyme has been studied as part of the commercial production of riboflavin.Liu Shuang Hu Wenya Wang Zhiwen Chen Tao Production of riboflavin and related cofactors by biotechnological processes Microbial Cell Factories 2020 19 1 31 10.1186/s12934-020-01302-7 free 32054466 7017516 References External links 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one+5'-monophosphate+deformylase Biology no Category:EC 3.5.1