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(KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase
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Class of enzymes
(KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase 2.4.99.15
(KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase (2.4.99.15, KDO transferase, waaA (gene), kdtA (gene), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:(KDO)3-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase ((2->4) glycosidic bond-forming). Brabetz W, Lindner B, Brade H Comparative analyses of secondary gene products of 3-deoxy-D-manno-oct-2-ulosonic acid transferases from Chlamydiaceae in Escherichia coli K-12 European Journal of Biochemistry 267 17 5458–65 September 2000 10951204 10.1046/j.1432-1327.2000.01619.x free Holst O, Bock K, Brade L, Brade H The structures of oligosaccharide bisphosphates isolated from the lipopolysaccharide of a recombinant Escherichia coli strain expressing the gene gseA [3-deoxy-D-manno-octulopyranosonic acid (Kdo) transferase] of Chlamydia psittaci 6BC European Journal of Biochemistry 229 1 194–200 April 1995 7744029 10.1111/j.1432-1033.1995.0194l.x free This enzyme catalyses the following chemical reaction
alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP
The enzyme from Chlamydia psittaci transfers four KDO residues to lipid A, forming a branched tetrasaccharide.
References
External links
(KDO)3-lipid+IVA+(2-4)+3-deoxy-D-manno-octulosonic+acid+transferase
Biology no
Category:EC 2.4.99