2-hydroxyethylphosphonate dioxygenase

Class of enzymes 2-hydroxyethylphosphonate dioxygenase 1.13.11.72 2-hydroxyethylphosphonate dioxygenase (1.13.11.72, HEPD, phpD (gene)) is an enzyme with systematic name 2-hydroxyethylphosphonate:O2 1,2-oxidoreductase (hydroxymethylphosphonate forming). Whitteck JT, Malova P, Peck SC, Cicchillo RM, Hammerschmidt F, van der Donk WA On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase Journal of the American Chemical Society 133 12 4236–9 March 2011 21381767 3069692 10.1021/ja1113326 2011JAChS.133.4236W Peck SC, Cooke HA, Cicchillo RM, Malova P, Hammerschmidt F, Nair SK, van der Donk WA Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase Biochemistry 50 30 6598–605 August 2011 21711001 3143709 10.1021/bi200804r This enzyme catalyses the following chemical reaction 60% Q27105414 2-hydroxyethylphosphonic acid O2 Q27106896 (hydroxymethyl)phosphonic acid + formic acid 0.3 2-hydroxyethylphosphonate dioxygenase contains non-heme-Fe(II) and is involved in the biosynthesis of phosphinothricin.1.13.11.72 Cicchillo RM, Zhang H, Blodgett JA, Whitteck JT, Li G, Nair SK, van der Donk WA, Metcalf WW An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis Nature 459 7248 871–4 June 2009 19516340 2874955 10.1038/nature07972 2009Natur.459..871C References External links 2-hydroxyethylphosphonate+dioxygenase Biology no Category:EC 1.13.11