(S)-tetrahydroprotoberberine N-methyltransferase

Class of enzymes (S)-tetrahydroprotoberberine N-methyltransferase 2.1.1.122 106878-42-6 0030782 (S)-tetrahydroprotoberberine N-methyltransferase (2.1.1.122) is an enzyme that catalyzes related methylation reactions in the biosynthesis of benzylisoquinoline alkaloids. 65% Q27102969 (S)-stylopine + SAM Q27105298 (S)-cis-N-methylstylopine + SAH For example, (S)-stylopine is converted to (S)-cis-N-methylstylopine. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from Eschscholtzia californica. It methylates (S)-canadine and (S)-tetrahydropalmatine in a similar way.Rueffer M, Zumstein G, Zenk MH 1990 Partial purification and characterization of S-adenosyl-L-methionine:(S)-tetrahydroprotoberberine cis-N-methyltransferase from suspension-cultured cells of Eschscholtzia and Corydalis Phytochemistry 29 3727–3733 10.1016/0031-9422(90)85321-6 12 https://epub.ub.uni-muenchen.de/3618/1/003.pdf This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase. This enzyme is also called tetrahydroprotoberberine cis-N-methyltransferase. It participates in alkaloid biosynthesis.2.1.1.122 References Biology no Category:EC 2.1.1 Category:Enzymes of unknown structure