15-oxoprostaglandin 13-oxidase

Class of enzymes 15-oxoprostaglandin 13-oxidase 1.3.1.48 57406-74-3 0047522 In enzymology, 15-oxoprostaglandin 13-oxidase (1.3.1.48) is an enzyme that catalyzes the chemical reaction 60% Q27283444 15-oxodihydroprostaglandin E1 + NAD+ reversible H+ H+ Q27098096 15-oxoprostaglandin E1 + NADH The two substrates of this enzyme are 15-oxodihydroprostaglandin E1 and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 15-oxoprostaglandin E1, reduced NADH, and a proton. The enzyme can also use nicotinamide adenine dinucleotide phosphate as an alternative cofactor.1.3.1.48 Hansen HS Purification and assay of 15-ketoprostaglandin Δ13-reductase from bovine lung Prostaglandins and Arachidonate Metabolites Methods in Enzymology 86 156–63 1982 6290839 10.1016/0076-6879(82)86186-7 978-0-12-181986-6 Jarabak J Isolation and properties of a 15-ketoprostaglandin Δ13-reductase from human placenta Prostaglandins and Arachidonate Metabolites Methods in Enzymology 86 163–7 1982 7132753 10.1016/0076-6879(82)86187-9 978-0-12-181986-6 This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase. Other names in common use include 15-oxo-Delta13-prostaglandin reductase, Delta13-15-ketoprostaglandin reductase, 15-ketoprostaglandin Delta13-reductase, prostaglandin Delta13-reductase, prostaglandin 13-reductase, and 15-ketoprostaglandin Delta13-reductase. Structural studies As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1V3T, 1V3U, 1V3V, and 2DM6. References Biology no Category:EC 1.3.1 Category:NADPH-dependent enzymes Category:NADH-dependent enzymes Category:Enzymes of known structure