2-Aminoethoxydiphenyl borate

changed changed 477197994 2-APB.png skin-invert-image 2-APB-3D-spacefill.png bg-transparent 2-APB molecule 2-[(Diphenylboranyl)oxy]ethan-1-amine 2-Aminoethyl diphenyl borateDiphenylborinic acid 2-aminoethyl ester2-Aminoethyl diphenylborinate 2-APB correct chemspider 1540 1/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2 BLZVCIGGICSWIG-UHFFFAOYAJ O(B(c1ccccc1)c2ccccc2)CCN correct EBI 169233 changed EBI 131184 208-366-5 E4ES684O93 C20698 correct chemspider 1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2 correct chemspider BLZVCIGGICSWIG-UHFFFAOYSA-N changed ?? 524-95-8 1598 2433 B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN 14 16 1 1 1 white 1.04g/cm3 192 to 194 325.3 at 760mmHg 150.6 07 Warning 302 315 319 335 261 264 270 271 280 301+312 302+352 304+340 305+351+338 312 321 330 332+313 337+313 362 403+233 405 501 2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptorsDiver J. M. Sage S. O. Rosado J. A. 2001-11-01 The inositol trisphosphate receptor antagonist 2-aminoethoxydiphenylborate (2-APB) blocks Ca2+ entry channels in human platelets: cautions for its use in studying Ca2+ influx Cell Calcium 30 5 323–329 10.1054/ceca.2001.0239 0143-4160 11733938 and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations).Xu Shang-Zhong Zeng Fanning Boulay Guylain Grimm Christian Harteneck Christian Beech David J. 2005-06-01 Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect British Journal of Pharmacology 145 4 405–414 10.1038/sj.bjp.0706197 0007-1188 1576154 15806115Bootman Martin D. Collins Tony J. Mackenzie Lauren Roderick H. Llewelyn Berridge Michael J. Peppiatt Claire M. 2002-08-01 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release FASEB Journal 16 10 1145–1150 10.1096/fj.02-0037rev free 1530-6860 12153982 43766251 https://lirias.kuleuven.be/handle/123456789/465704 subscription In research it is used to manipulate intracellular release of calcium ions (Ca2+) and modify TRP channel activity, although the lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions made of connexin.Bai Donglin del Corsso Cristiane Srinivas Miduturu Spray David C. 2006-12-01 Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB) The Journal of Pharmacology and Experimental Therapeutics 319 3 1452–1458 10.1124/jpet.106.112045 0022-3565 16985167 2375567 Increasing evidence showed that 2-APB is a powerful modifier of store-operated calcium channels (SOC) function, low concentration of 2-APB can enhance SOC while high concentration induces a transient increase followed by complete inhibition.Ma HT, et al. (2000) Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels. Science 287:1647–1651.Prakriya M, Lewis RS (2001) Potentiation and inhibition of Ca2+ release-activated Ca2+ channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP 3 receptors. J Physiol 536:3–19.Ma HT, Venkatachalam K, Parys JB, Gill DL (2002) Modification of store-operated channel coupling and inositol trisphosphate receptor function by 2-aminoethoxydiphenyl borate in DT40 lymphocytes. J Biol Chem 277:6915–6922. References Category:Organoboron compounds Category:Phenyl compounds Category:Aminoethyl compounds