2',3'-cyclic-nucleotide 2'-phosphodiesterase

Class of enzymes 2′,3′-cyclic-nucleotide 2′-phosphodiesterase 3.1.4.16 9037-18-7 0008663 The enzyme 2′,3′-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) catalyzes the general reaction nucleoside 2′,3′-cyclic phosphate + H2O nucleoside 3′-phosphate For example, the enzyme characterised from Escherichia coli, 2',3'-cyclic AMP is hydrolysed to 3'-adenylic acid: Anraku Y 1964 A new cyclic phosphodiesterase having a 3′-nucleotidase activity from Escherichia coli B. I. purification and some properties of the enzyme J. Biol. Chem. 239 10 3412–9 10.1016/S0021-9258(18)97738-0 free 14245396 Anraku Y 1964 A new cyclic phosphodiesterase having a 3′-nucleotidase activity from Escherichia coli B. II. Further studies on substrate specificity and mode of action of the enzyme J. Biol. Chem. 239 10 3420–4 10.1016/S0021-9258(18)97739-2 free 14245397 Rao Feng Qi Yaning Murugan Elavazhagan Pasunooti Swathi Ji Qiang 2′,3′-cAMP hydrolysis by metal-dependent phosphodiesterases containing DHH, EAL, and HD domains is non-specific: Implications for PDE screening Biochemical and Biophysical Research Communications 2010 398 3 500–505 10.1016/j.bbrc.2010.06.107 20599695 65% Q27103372 2',3'-cyclic AMP H2O Q27103969 3'-adenylic acid Similar activity has been found in preparations from Proteus mirabilis, bovine brain, and Vibrio alginolyticus.Center MS, Behal FJ 1968 A cyclic phosphodiesterase with 3′-nucleotidase activity from Proteus mirabilis J. Biol. Chem. 243 138–43 4295113 1 10.1016/S0021-9258(18)99334-8 free Olafson RW, Drummond GI, Lee JF 1969 Studies on 2′,3'-cyclic nucleotide-3'-phosphohydrolase from brain Can. J. Biochem. 47 961–6 4310670 10 10.1139/o69-151Unemoto T, Hayashi M 1969 Chloride ion as a modifier of 2′,3′-cyclic phosphodiesterase purified from halophilic Vibrio alginolyticus Biochim. Biophys. Acta 171 89–102 4303200 1 10.1016/0005-2744(69)90108-9 This enzyme is a hydrolase, specifically one acting on phosphoric diester bonds. The systematic name is nucleoside-2′,3′-cyclic-phosphate 3'-nucleotidohydrolase. Other names in use include ribonucleoside 2′,3′-cyclic phosphate diesterase, 2′,3′-cyclic AMP phosphodiesterase, 2′,3′-cyclic nucleotidase, cyclic 2′,3′-nucleotide 2′-phosphodiesterase, cyclic 2′,3′-nucleotide phosphodiesterase, 2′,3′-cyclic nucleoside monophosphate phosphodiesterase, 2′,3′-cyclic AMP 2′-phosphohydrolase, cyclic phosphodiesterase:3′-nucleotidase, 2′,3′-cyclic nucleotide phosphohydrolase, 2′:3′-cyclic phosphodiesterase, and 2′:3′-cyclic nucleotide phosphodiesterase:3'-nucleotidase.3.1.4.16 References Biology no Category:EC 3.1.4 Category:Enzymes of unknown structure