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1cP-LSD
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Chemical compound
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1cP-LSD.svg skin-invert-image 200px 1cP-LSD 3D.png bg-transparent 225px Oral Serotonergic psychedelic; Hallucinogen S9 F2 Unscheduled. NpSG PSA 5–10 hours 2767597-50-0 155884675 107450612 7UU7S6TN3J 1-CPA-LSD; 1-Cyclopropanoyl-LSD; 1-Cyclopropionyl-LSD; 1-(Cyclopropylmethanoyl)-LSD; 1cP; Curie (6aR,9R)-N,N-diethyl-7-methyl-4-cyclopropylmethanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide 24 29 3 2 CCN(CC)C(=O)[C@@H]5C=C2[C@@H](Cc3cn(C(=O)C1CC1)c4cccc2c34)N(C)C5 1S/C24H29N3O2/c1-4-26(5-2)23(28)17-11-19-18-7-6-8-20-22(18)16(12-21(19)25(3)13-17)14-27(20)24(29)15-9-10-15/h6-8,11,14-15,17,21H,4-5,9-10,12-13H2,1-3H3/t17-,21-/m1/s1 RAFUPYYDHPFASC-DYESRHJHSA-N
1cP-LSD, also known as 1-cyclopropanoyl-LSD or by the nickname Curie, is a psychedelic drug of the lysergamide family and an acylated derivative of lysergic acid diethylamide (LSD) which has been sold as a designer drug. Tanaka R, Kawamura M, Hakamatsuka T, Kikura-Hanajiri R [Identification of LSD Derivatives, 1cP-LSD, MIPLA and 1B-LSD in Illegal Products as Paper Sheet] Yakugaku Zasshi 140 11 1405–1413 2020 33132277 10.1248/yakushi.20-00124 free Vincenti F, Gregori A, Flammini M, Di Rosa F, Salomone A Seizures of New Psychoactive Substances on the Italian territory during the COVID-19 pandemic Forensic Science International 326 September 2021 34371393 8411784 10.1016/j.forsciint.2021.110904 110904 1cP-LSD АИПСИН https://aipsin.com/newsubstance/250/ ru 1 January 2026 It is a prodrug of LSD.
Use and effects
LSD#Uses LSD#Effects
1cP-LSD has been used in the form of blotter tabs containing 100μg 1cP-LSD free base and pellets containing 150μg 1cP-LSD hemitartrate. Its dose is said to be 100 to 200μg and it has comparable potency to 1P-LSD and 1B-LSD. Its duration has been said to be 5 to 10hours.1cP-LSD АИПСИН https://aipsin.com/newsubstance/324/ ru 1 January 2026
Interactions
Psychedelic drug#Interactions Trip killer#Serotonergic psychedelic antidotes
Pharmacology
Pharmacodynamics
1cP-LSD is a prodrug of LSD. It has been found to produce psychedelic-like effects, specifically the head-twitch response, in rodents with similar potency as 1P-LSD. Brandt SD, Kavanagh PV, Westphal F, Stratford A, Odland AU, Klein AK, Dowling G, Dempster NM, Wallach J, Passie T, Halberstadt AL Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD) Drug Testing and Analysis 12 6 812–826 June 2020 32180350 9191646 10.1002/dta.2789
Chemistry
Analogues
Related compounds include 1B-LSD, 1DD-LSD, 1P-LSD, 1V-LSD, ALD-52 (1A-LSD), 1cP-AL-LAD, AL-LAD, ETH-LAD, 1P-ETH-LAD, PRO-LAD, LSM-775, and LSZ, among others.
Society and culture
Legal status
thumb|left|200px|1cP-LSD on blotter paper.
Canada
1cP-LSD is not a controlled substance in Canada as of 2025.Controlled Drugs and Substances Act Department of Justice Canada https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 19 January 2026
Sweden
Sweden's public health agency suggested classifying 1cP-LSD as a dangerous substance on 18 December 2019 and later classified it as such on 22 April 2021. Förordning (1999:58) om förbud mot vissa hälsofarliga varor https://www.riksdagen.se/sv/dokument-lagar/dokument/svensk-forfattningssamling/forordning-199958-om-forbud-mot-vissa_sfs-1999-58/ Tjugotre ämnen föreslås klassas som narkotika eller hälsofarlig vara December 18, 2019 https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2019/december/tjugotre-amnen-foreslas-klassas-som-narkotika-eller-halsofarlig-vara/ Twenty-three substances are proposed to be classified as drugs or dangerous goods Folkhälsomyndigheten sv May 28, 2020 November 24, 2022 https://web.archive.org/web/20221124162527/https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2019/december/tjugotre-amnen-foreslas-klassas-som-narkotika-eller-halsofarlig-vara/ dead
United States
1cP-LSD is not an explicitly controlled substance in the United States. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) January 2026 U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division United States https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.
Research
1cP-LSD has been investigated as a potential treatment for anxiety in dogs and cats. Hernández-Álvarez E, Borkel LF, Rojas-Hernández J, Quintana-Hernández DJ, García-Serrano I, Fernández-Borkel T, Zumbado M, Henríquez-Hernández LA Evaluating the Potential of Microdosing 1cp-LSD for the Treatment of Canine Anxiety: A One-Month Case Study Veterinary Medicine and Science 11 4 July 2025 40638522 12244264 10.1002/vms3.70486 e70486 free Hernández-Álvarez E, Rojas-Hernández J, Borkel LF, Quintana-Hernández DJ, Fernández-Borkel T, Henríquez-Hernández LA Preliminary Findings on Low-Dose 1cp-LSD for Canine Anxiety: Exploring the Role of Owner Neuroticism and Psychopathology Veterinary Sciences 12 9 872 September 2025 41012797 10.3390/vetsci12090872 12474181 free Hernández-Álvarez E, Canino-Quijada C, Roiz S, Luzardo OP, Henríquez-Hernández LA Evaluation of 1cp-LSD for Enhancing Welfare in Shelter Dogs: A Randomized Blind Trial with Ethological Intervention Vet Sci 13 1 January 2026 96 41600753 12846581 10.3390/vetsci13010096 free
See also
Substituted lysergamide
Lizard Labs
References
External links
1cP-LSD - Isomer Design
1cP-LSD - PsychonautWiki
The Small & Handy 1cP-LSD Thread - Bluelight
1cP-LSD - Lysergamide Psychedelics - TripSitter
Category:5-HT2A agonists
Category:Cyclopropyl compounds
Category:Designer prodrugs
Category:Diethylamides
Category:Lizard Labs
Category:Methyl compounds
Category:Psychedelic lysergamides
Category:Serotonin receptor agonists