2-MAPB

Chemical compound 2-MAPB 2-MAPB structure.svg skin-invert-image 225px 12 15 1 1 1-(1-benzofuran-2-yl)-N-methylpropan-2-amine correct CAS 806596-15-6 correct FDA W5G20WN7CL 476194 547092 CC(CC1=CC2=CC=CC=C2O1)NC 1S/C12H15NO/c1-9(13-2)7-11-8-10-5-3-4-6-12(10)14-11/h3-6,8-9,13H,7H2,1-2H3 ANJIDHKQUCZNQY-UHFFFAOYSA-N 2-MAPB is a recreational designer drug with empathogenic effects. As with other related substituted benzofuran derivatives such as 6-APB and 5-MAPB, 2-MAPB is a monoamine releaser with some selectivity for serotonin release, generally similar in pharmacological profile to MDMA but with greater activity as a directly acting agonist of 5-HT2 receptor subtypes and somewhat greater toxicity. Fuwa T, Suzuki J, Tanaka T, Inomata A, Honda Y, Kodama T Novel psychoactive benzofurans strongly increase extracellular serotonin level in mouse corpus striatum The Journal of Toxicological Sciences 2016 41 3 329–337 27193726 10.2131/jts.41.329 free 2-MAPB has been isolated from post-mortem toxicology screens in several drug-related fatal adverse reactions but generally only as a component of combinations of drugs, making it difficult to determine how much it contributed to the deaths. Staeheli SN, Boxler MI, Oestreich A, Marti M, Gascho D, Bolliger SA, Kraemer T, Steuer AE 6 Postmortem distribution and redistribution of MDAI and 2-MAPB in blood and alternative matrices Forensic Science International 279 83–87 October 2017 28850871 10.1016/j.forsciint.2017.08.007 31183795 https://www.zora.uzh.ch/id/eprint/141467/2/doi.org10.1016j.forsciint.2017.08.007.pdf Theofel N, Budach D, Vejmelka E, Scholtis S, Tsokos M Toxicological investigations in a death involving 2-MAPB Forensic Science, Medicine, and Pathology 17 2 317–321 June 2021 33877515 10.1007/s12024-021-00366-0 1547-769X 233309570 It is illegal in Japan.http://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/dl/meisho.pdf 指定薬物名称・構造式一覧（平成27年9月16日現在） 厚生労働省 16 September 2015 ja 23 August 2016 See also Substituted benzofuran Benzofuranylpropylaminopentane Dimemebfe 5-Methylmethiopropamine Methamnetamine References Category:Benzofuranethanamines Category:Designer drugs Category:Entactogens Category:Secondary amines