15-hydroxyprostaglandin-D dehydrogenase (NADP+)

Class of enzymes {{DISPLAYTITLE:15-hydroxyprostaglandin-D dehydrogenase (NADP+)}} 15-hydroxyprostaglandin-D dehydrogenase (NADP+) 1.1.1.196 84399-95-1 0047020 In enzymology, 15-hydroxyprostaglandin-D dehydrogenase (NADP+) (1.1.1.196) is an enzyme that catalyzes the chemical reaction 60% prostaglandin D2 + NADP+ reversible H+ H+ Q27098099 15-dehydro-prostaglandin D2 + NADPH Thus, the two substrates of this enzyme are prostaglandin D2 and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are 15-dehydro-prostaglandin D2, reduced NADPH, and a proton.1.1.1.196Watanabe K, Shimizu T, Iguchi S, Wakatsuka H, Hayashi M, Hayaishi O 1980 An NADP-linked prostaglandin D dehydrogenase in swine brain J. Biol. Chem. 255 1779–82 7354056 5 10.1016/S0021-9258(19)85944-6 free This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase. Other names in common use include prostaglandin-D 15-dehydrogenase (NADP+), dehydrogenase, prostaglandin D2, NADP+-PGD2 dehydrogenase, dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine, dinucleotide phosphate), 15-hydroxy PGD2 dehydrogenase, 15-hydroxyprostaglandin dehydrogenase (NADP+), NADP+-dependent 15-hydroxyprostaglandin dehydrogenase, prostaglandin D2 dehydrogenase, NADP+-linked 15-hydroxyprostaglandin dehydrogenase, NADP+-specific 15-hydroxyprostaglandin dehydrogenase, NADP+-linked prostaglandin D2 dehydrogenase, and 15-hydroxyprostaglandin-D dehydrogenase (NADP+). This enzyme participates in arachidonic acid metabolism. References Biology no Category:EC 1.1.1 Category:NADPH-dependent enzymes Category:Enzymes of unknown structure