(carboxyethyl)arginine beta-lactam-synthase

Class of enzymes (Carboxyethyl)arginine β-lactam-synthase 6.3.3.4 68247-54-1 0034027 1mc1.png beta-lactam synthetase. PDB 1mc1 Miller M. T. Bachmann B. O. Townsend C. A. Rosenzweig A. C. The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots 10.1073/pnas.232361199 Proceedings of the National Academy of Sciences 99 23 14752–14757 2002 12409610 137491 2002PNAS...9914752M free In enzymology, a (carboxyethyl)arginine β-lactam-synthase (6.3.3.4) is an enzyme that catalyzes the chemical reaction File:(carboxyethyl)arginine beta-lactam-synthase.svg ATP + L-N2-(2-carboxyethyl)arginine AMP + diphosphate + deoxyamidinoproclavaminate Thus, the two substrates of this enzyme are ATP and L-N2-(2-carboxyethyl)arginine, whereas its 3 products are AMP, diphosphate, and deoxyamidinoproclavaminate. This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme is also called L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme participates in clavulanic acid biosynthesis. References Further reading Zhou J, Kelly WL, Bachmann BO, Gunsior M, Townsend CA, Solomon EI Edward I. Solomon 2001 Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities J. Am. Chem. Soc. 123 7388–98 11472170 10.1021/ja004025+ 30 2001JAChS.123.7388Z Townsend CA 2002 New reactions in clavulanic acid biosynthesis Curr. Opin. Chem. Biol. 6 583–9 12413541 10.1016/S1367-5931(02)00392-7 5 Bachmann BO, Li R, Townsend CA 1998 β-Lactam synthetase: A new biosynthetic enzyme Proc. Natl. Acad. Sci. 95 9082–6 9689037 10.1073/pnas.95.16.9082 16 21295 1998PNAS...95.9082B free Biology no Category:EC 6.3.3 Category:Enzymes of unknown structure