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1SB-LSD
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1SB-LSD.svg skin-invert-image 250px Oral Serotonergic psychedelic; Hallucinogen None 1BS-LSD; 1-TMSBz-LSD; 1-(4-(Trimethylsilyl)benzoyl)-LSD 30 36 3 2 1 CCN(CC)C(=O)[C]1CN(C)[C@@H]2Cc3cn(C(=O)c4ccc(cc4)[Si](C)(C)C)c5cccc(C2=C1)c35 1S/C30H36N3O2Si/c1-7-32(8-2)29(34)22-16-25-24-10-9-11-26-28(24)21(17-27(25)31(3)18-22)19-33(26)30(35)20-12-14-23(15-13-20)36(4,5)6/h9-16,19,27H,7-8,17-18H2,1-6H3/t27-/m1/s1 SLFZGAWRMZEIEW-HHHXNRCGSA-N
1SB-LSD, or 1BS-LSD, also known as 1-TMSBz-LSD or as 1-(4-(trimethylsilyl)benzoyl)-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).1BS-LSD AIPSIN https://aipsin.com/newsubstance/1823/ ru 1 January 2026 Tanaka R, Kawamura M, Ito M, Kikura-Hanajiri R Identification and Analysis of Lysergic Acid Diethylamide Analogs, 4-Benzoyl-N,N-Diethyl-7-Methyl-4,6,6a,7,8,9-Hexahydroindolo[4,3-fg]quinoline-9-Carboxamide (1Bz-LSD) and N,N-Diethyl-7-Methyl-4-(4-(Trimethylsilyl)Benzoyl)-4,6,6a,7,8,9-Hexahydroindolo[4,3-fg]quinoline-9-Carboxamide (1-TMSBz-LSD), in tablet or paper sheet products available online in Japan Drug Test Anal 18 4 510–517 April 2026 41709646 10.1002/dta.70039 It is thought to be a prodrug of LSD. The drug was encountered online as a novel designer drug in September 2025. 1SB-LSD has been sold in the form of blotter, for instance containing 165μg per tab. It is the derivative of 1Bz-LSD (SYN-L-018) in which there is a 4-trimethylsilyl group on the benzyl ring. WO 2024/028495 Stratford A, Williamson JP Synex Holdings BV Prodrugs of Substituted Ergolines https://patents.google.com/patent/WO2024028495A1/ 8 February 2024 1SB-LSD was first described in the scientific literature by 2026. It is not an explicitly controlled substance in the United States Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) January 2026 U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division United States https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf or in Canada.Controlled Drugs and Substances Act Department of Justice Canada 5 December 2025 https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 20 January 2026
See also
Substituted lysergamide
References
Category:Benzyl compounds
Category:Designer prodrugs
Category:Diethylamides
Category:Psychedelic lysergamides
Category:Trimethylsilyl compounds