2-APQC

vanc 6 2-APQC_structure.png skin-invert-image Sirtuin-3 (SIRT3) activator 500271-63-6 1965265 1499078 2-amino-1-[(4-fluorophenyl)methyl]-N-pentylpyrrolo[3,2-b]quinoxaline-3-carboxamide 23 24 1 5 1 CCCCCNC(=O)C1=C(N(C2=NC3=CC=CC=C3N=C12)CC4=CC=C(C=C4)F)N 1S/C23H24FN5O/c1-2-3-6-13-26-23(30)19-20-22(28-18-8-5-4-7-17(18)27-20)29(21(19)25)14-15-9-11-16(24)12-10-15/h4-5,7-12H,2-3,6,13-14,25H2,1H3,(H,26,30) FYNPHMNXVLLDAS-UHFFFAOYSA-N 2-APQC is a drug which acts as a sirtuin-3 (SIRT3) activator. In animal studies, it improved muscle and heart function in aged mice. Peng F, Liao M, Jin W, Liu W, Li Z, Fan Z, Zou L, Chen S, Zhu L, Zhao Q, Zhan G, Ouyang L, Peng C, Han B, Zhang J, Fu L 2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis Signal Transduction and Targeted Therapy 9 1 133 May 2024 38744811 10.1038/s41392-024-01816-1 free 11094072 Xu C, Xiong L, Chen J, Liu Q, Wang F, Fu X, Huo J, Bu Y, Chen S, Liu Q Sirtuin 3 modulation by high phosphates: a potential mechanism in muscle aging and sarcopenia American Journal of Translational Research 2025 17 6 4187–4197 40672597 10.62347/JWEY8421 12261155 References Category:Amides Category:Amines Category:Benzyl compounds Category:4-Fluorophenyl compounds Category:Pentyl compounds Category:Pyrroloquinoxalines