(d)CMP kinase

Class of enzymes (d)CMP kinase 2.7.4.25 (d)CMP kinase (2.7.4.25, prokaryotic cytidylate kinase, deoxycytidylate kinase, dCMP kinase, deoxycytidine monophosphokinase) is an enzyme with systematic name ATP:(d)CMP phosphotransferase.2.7.4.25 It catalyses two related chemical reactions. The first converts the nucleotide, cytidine monophosphate (CMP), to cytidine diphosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP): Bertrand T, Briozzo P, Assairi L, Ofiteru A, Bucurenci N, Munier-Lehmann H, Golinelli-Pimpaneau B, Bârzu O, Gilles AM Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme Journal of Molecular Biology 315 5 1099–110 February 2002 11827479 10.1006/jmbi.2001.5286 60% cytidine monophosphate reversible ATP ADP ADP ATP cytidine diphosphate 1.2 Alternatively, the enzyme can act on deoxycytidine monophosphate (dCMP): Thum C, Schneider CZ, Palma MS, Santos DS, Basso LA The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP Journal of Bacteriology 191 8 2884–7 April 2009 19181797 2668428 10.1128/jb.01337-08 60% deoxycytidine monophosphate reversible ATP ADP ADP ATP deoxycytidine diphosphate This prokaryotic enzyme is specific for CMP or dCMP. References External links (d)CMP+kinase Biology no Category:EC 2.7.4