(+)-alpha-pinene synthase

Class of enzymes (+)-α-pinene synthase 4.2.3.121 (+)-α-pinene synthase (EC 4.2.3.121, (+)-α-pinene cyclase, cyclase I) is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-α-pinene-forming]. Gambliel H, Croteau R Pinene cyclases I and II. Two enzymes from sage (Salvia officinalis) which catalyze stereospecific cyclizations of geranyl pyrophosphate to monoterpene olefins of opposite configuration The Journal of Biological Chemistry 259 2 740–8 January 1984 10.1016/S0021-9258(17)43520-4 free 6693393 Croteau R, Satterwhite DM, Cane DE, Chang CC Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (−)-linalyl pyrophosphate to (+)- and (−)-pinene and (+)- and (−)-camphene The Journal of Biological Chemistry 263 21 10063–71 July 1988 10.1016/S0021-9258(19)81477-1 free 3392006 Wagschal KC, Pyun HJ, Coates RM, Croteau R Monoterpene biosynthesis: isotope effects associated with bicyclic olefin formation catalyzed by pinene synthases from sage (Salvia officinalis) Archives of Biochemistry and Biophysics 308 2 477–87 February 1994 8109978 10.1006/abbi.1994.1068 Pyun HJ, Wagschal KC, Jung DI, Coates RM, Croteau R Stereochemistry of the proton elimination in the formation of (+)- and (−)-α-pinene by monoterpene cyclases from sage (Salvia officinalis) Archives of Biochemistry and Biophysics 308 2 488–96 February 1994 8109979 10.1006/abbi.1994.1069 Phillips MA, Savage TJ, Croteau R Monoterpene synthases of loblolly pine (Pinus taeda) produce pinene isomers and enantiomers Archives of Biochemistry and Biophysics 372 1 197–204 December 1999 10562434 10.1006/abbi.1999.1467 Phillips MA, Wildung MR, Williams DC, Hyatt DC, Croteau R cDNA isolation, functional expression, and characterization of (+)-α-pinene synthase and (−)-α-pinene synthase from loblolly pine (Pinus taeda): stereocontrol in pinene biosynthesis Archives of Biochemistry and Biophysics 411 2 267–76 March 2003 12623076 10.1016/s0003-9861(02)00746-4 This enzyme catalyses the following chemical reaction geranyl diphosphate (+)-α-pinene + diphosphate Cyclase I of Salvia officinalis (sage) gives about equal parts (+)-α-pinene and (+)-camphene. References External links (+)-alpha-pinene+synthase Biology no Category:EC 4.2.3