2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

Class of enzymes 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase 1.1.1.127 37250-56-9 0047001 In enzymology, 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (1.1.1.127) is an enzyme that catalyzes the chemical reaction 50% Q27102179 2-dehydro-3-deoxy-D-gluconic acid + NAD+ reversible H+ H+ Q27098152 (4S)-4,6-dihydroxy-2,5-dioxohexanoic acid + NADH The two substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are (4S)-4,6-dihydroxy-2,5-dioxohexanoic acid, reduced NADH, and a proton.1.1.1.127 Condemine G Hugouvieux-Cotte-Pattat N Robert-Baudouy J 1984 An enzyme in the pectolytic pathway of Erwinia chrysanthemi: 3-keto-3-deoxygluconate oxidoreductase J. Gen. Microbiol. 130 11 2839–2844 10.1099/00221287-130-11-2839 free Preiss J, Ashwell G Polygalacturonic acid metabolism in bacteria. II. Formation and metabolism of 3-deoxy-D-glycero-2, 5-hexodiulosonic acid The Journal of Biological Chemistry 238 1577–83 May 1963 5 10.1016/S0021-9258(18)81103-6 free 13986017 This enzyme participates in pentose and glucuronate interconversions. Nomenclature This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase. Other names in common use include 2-keto-3-deoxygluconate 5-dehydrogenase, 2-keto-3-deoxy-D-gluconate dehydrogenase, 2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide, (phosphate)) dehydrogenase, 2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic, and acid) dehydrogenase. References Biology no Category:EC 1.1.1 Category:NADH-dependent enzymes Category:Enzymes of unknown structure