1-phosphatidylinositol 4-kinase

Class of enzymes 1-phosphatidylinositol 4-kinase 2.7.1.67 37205-54-2 0004430 4hnd.jpg 270 Phosphatidylinositol 4-kinase homo16mer, Human In enzymology, a 1-phosphatidylinositol 4-kinase (2.7.1.67) is an enzyme that catalyzes the chemical reaction ATP + 1-phosphatidyl-1D-myo-inositol ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 4-phosphate. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase. Other names in common use include phosphatidylinositol kinase (phosphorylating), phosphatidylinositol 4-kinase, phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. Structural studies As of late 2007, the structure has only been solved for this enzyme. Part of the enzyme was crystallized with its activating partner frequenin.Strahl T Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1) J. Biol. Chem. 282 42 30949–59 17720810 10.1074/jbc.M705499200 vanc Huttner IG Lusin JD 3 Osawa M. King D. Thorner J. Ames J. B. October 2007 free References 1 Further reading Colodzin M, Kennedy EP 1965 Biosynthesis of diphosphoinositide in brain J. Biol. Chem. 240 3771–80 4284712 10 10.1016/S0021-9258(18)97109-7 free Kai M, White GL, Hawthorne JN 1966 The phosphatidylinositol kinase of rat brain Biochem. J. 101 328–37 4290722 2 10.1042/bj1010328 1270113 Walker DH, Dougherty N, Pike LJ 1988 Purification and characterization of a phosphatidylinositol kinase from A431 cells Biochemistry 27 6504–11 2851325 10.1021/bi00417a046 17 Whitman M, Downes CP, Keeler M, Keller T, Cantley L 1988 Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate Nature 332 644–6 2833705 10.1038/332644a0 6165 1988Natur.332..644W 4326568 Barylko B 2001 A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans J. Biol. Chem. 276 7705–8 11244087 10.1074/jbc.C000861200 Gerber SH Binns DD Grichine N Khvotchev M Südhof TC Albanesi JP 11 free Biology no Category:EC 2.7.1 Category:Enzymes of known structure