(R)-2-hydroxyacid dehydrogenase

Class of enzymes (R)-2-hydroxyacid dehydrogenase 1.1.1.272 0050578 In enzymology, a (R)-2-hydroxyacid dehydrogenase (1.1.1.272) is an enzyme that catalyzes the chemical reaction (2R)-3-sulfolactate + NAD(P)+ 3-sulfopyruvate + NAD(P)H + H+ The 3 substrates of this enzyme are (2R)-3-sulfolactic acid, NAD+, and NADP+, whereas its 4 products are 3-sulfopyruvic acid, NADH, NADPH, and H+. This enzyme is important in the metabolism of archaea, particularly their biosynthesis of coenzymes such as coenzyme M, tetrahydromethanopterin and methanofuran.Graupner M, Xu H, White RH 2000 Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea J. Bacteriol. 182 3688–92 10850983 10.1128/JB.182.13.3688-3692.2000 13 94539 This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-2-hydroxyacid:NAD(P)+ oxidoreductase. Other names in common use include (R)-sulfolactate:NAD(P)+ oxidoreductase, L-sulfolactate dehydrogenase, ComC, and (R)-sulfolactate dehydrogenase. Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1RFM. References 1 Further reading Graupner M, White RH 2001 The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea Biochim. Biophys. Acta 1548 169–73 11451450 1 10.1016/S0167-4838(01)00220-5 Graham DE, White RH 2002 Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics Nat. Prod. Rep. 19 133–47 12013276 10.1039/b103714p 2 Biology no Category:EC 1.1.1 Category:NADPH-dependent enzymes Category:NADH-dependent enzymes Category:Enzymes of known structure