11-Dehydrothromboxane B2

changed changed 477199020 11-Dehydrothromboxane B2.svg (5Z,9S,13E,15S)-9,15-Dihydroxy-11-oxothromboxa-5,13-dien-1-oic acid (5Z)-7-{(2R,3S,4S)-4-Hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-6-oxooxan-3-yl}hept-5-enoic acid 11-Dehydro-thromboxane B2 4484 KJYIVXDPWBUJBQ-UHHGALCXBE correct chemspider 1S/C20H32O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+/m0/s1 correct chemspider KJYIVXDPWBUJBQ-UHHGALCXSA-N changed ?? 67910-12-7 correct FDA CJ6ST9UG7C 5280891 correct chemspider 4444414 correct EBI 28667 correct kegg C05964 O=C1O[C@H](/C=C/[C@@H](O)CCCCC)[C@H]([C@@H](O)C1)C\C=C/CCCC(=O)O 1/C20H32O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+/m0/s1 20 32 6 368.46 11-Dehydrothromboxane B2 (or 11-dehydro-TXB2) is produced from the breakdown of thromboxane A2. It is released by activated platelets and urine levels of 11-dehydro-TXB2 can be used to monitor the response to aspirin therapy when used to prevent heart diseaseLordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease Eur Heart J 2007 28 14 1702–1708 10.1093/eurheartj/ehm226 17569678 free and in diseases where platelet activation is prominent.10.1073/pnas.83.16.5861 11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation Catella F, Healy D, Lawson JA, FitzGerald GA PNAS 1986 83 16 5861–5865 3461463 386396 1986PNAS...83.5861C free References Category:Eicosanoids