2-methylacyl-CoA dehydrogenase

Class of enzymes 2-methylacyl-CoA dehydrogenase 1.3.99.12 85130-32-1 0003853 In enzymology, a 2-methylacyl-CoA dehydrogenase (1.3.99.12) is an enzyme that catalyzes the chemical reaction 2-methylbutanoyl-CoA + acceptor 2-methylbut-2-enoyl-CoA + reduced acceptor Thus, the two substrates of this enzyme are 2-methylbutanoyl-CoA and acceptor, whereas its two products are 2-methylbut-2-enoyl-CoA and reduced acceptor. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 2-methylbutanoyl-CoA:acceptor oxidoreductase. Other names in common use include branched-chain acyl-CoA dehydrogenase, 2-methyl branched chain acyl-CoA dehydrogenase, and 2-methylbutanoyl-CoA:(acceptor) oxidoreductase. This enzyme participates in valine, leucine and isoleucine degradation. References 1 Ikeda Y, Dabrowski C, Tanaka K 1983 Separation and properties of five distinct acyl-CoA dehydrogenases from rat liver mitochondria. Identification of a new 2-methyl branched chain acyl-CoA dehydrogenase J. Biol. Chem. 258 1066–76 6401712 2 10.1016/S0021-9258(18)33160-0 free Biology no Category:EC 1.3.99 Category:Enzymes of unknown structure