1F-LSD

1-Formyl-LSD 1F-LSD structure.svg skin-invert-image 225px Oral Serotonin receptor agonist; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen None 170763729 1-(2-Furoyl)-LSD; 1-(Furan-2-carbonyl)-LSD; SYN-L-005; N,N-Diethyl-1-(furan-2-carbonyl)-6-methyl-9,10-didehydroergoline-8β-carboxamide (6aR,9R)-N,N-diethyl-4-(furan-2-carbonyl)-7-methyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide 25 27 3 3 CCN(CC)C(=O)[C@H]1CN([C@@H]2CC3=CN(C4=CC=CC(=C34)C2=C1)C(=O)C5=CC=CO5)C 1S/C25H27N3O3/c1-4-27(5-2)24(29)17-12-19-18-8-6-9-20-23(18)16(13-21(19)26(3)14-17)15-28(20)25(30)22-10-7-11-31-22/h6-12,15,17,21H,4-5,13-14H2,1-3H3/t17-,21-/m1/s1 VHDXVHVDSPZVCI-DYESRHJHSA-N 1F-LSD, also known as 1-(2-furoyl)-LSD or as SYN-L-005, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). Brandt SD, Kavanagh PV, Gare S, Elliott SP, Stratford A, Halberstadt AL Analytical and Pharmacological Characterization of 1-(Furan-2-Carbonyl)-LSD (1F-LSD) and Comparison With 1-(Thiophene-2-Carbonyl)-LSD (1T-LSD) Drug Test Anal 17 8 1283–1293 August 2025 39624022 12319525 10.1002/dta.3829 WO 2024/028495 Stratford A, Williamson JP Synex Holdings BV Prodrugs of Substituted Ergolines https://patents.google.com/patent/WO2024028495A1/ 8 February 2024 It is thought to act as a prodrug of LSD. The drug interacts with serotonin receptors, including the serotonin 5-HT2A receptor, and produces the head-twitch response in rodents, with about 3-fold lower potency than LSD. It hydrolyzes into LSD in rodents. 1F-LSD was patented in 2024 and was first described in the scientific literature in 2025. It has been encountered as a novel designer drug in Germany and Japan. Use and effects LSD#Uses LSD#Effects Interactions Psychedelic drug#Interactions Trip killer#Serotonergic psychedelic antidotes Chemistry Analogues Analogues of 1F-LSD include 1P-LSD, 1cP-LSD, 1B-LSD, 1S-LSD, and 1T-LSD, among others. Society and culture Legal status Canada 1F-LSD is not an explicitly nor implicitly controlled substance in Canada as of 2025.Controlled Drugs and Substances Act Department of Justice Canada 5 December 2025 https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 20 January 2026 United States 1F-LSD is not an explicitly controlled substance in the United States. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) January 2026 U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division United States https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption. See also Substituted lysergamide Lizard Labs References External links 1-(Furan-2-carbonyl)-LSD - Isomer Design Category:5-HT2A agonists Category:Carbonyl compounds Category:Designer prodrugs Category:Diethylamides Category:2-Furyl compounds Category:Lizard Labs Category:Psychedelic lysergamides Category:Serotonin receptor agonists