11C-UCB-J

11C-UCB-J.svg skin-invert-image 200px (4R)-1-{[3-(11C)Methylpyridin-4-yl]methyl}-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one [11C]UCB-J; 11C-UCB-J; [11C]UCB-J 2098041-11-1 correct CAS 103882818 correct FDA 99PJR3QL3Y 74539761 1S/C17H15F3N2O/c1-10-7-21-3-2-11(10)8-22-9-13(6-16(22)23)12-4-14(18)17(20)15(19)5-12/h2-5,7,13H,6,8-9H2,1H3/t13-/m0/s1/i1-1 RFSDYRVOGWHOFT-XOTOJZTHSA-N [11CH3]C1=CN=CC=C1CN1C[C@H](CC1=O)C1=CC(F)=C(F)C(F)=C1 17 15 3 2 1 11C-UCB-J is a PET tracer for imaging the synaptic vesicle glycoprotein 2A in the human brain. Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain 26848175 10.2967/jnumed.115.168179 57 5 777–84 Nabulsi NB Mercier J Holden D Carré S Najafzadeh S Vandergeten MC Lin SF Deo A Price N Wood M Lara-Jaime T Montel F Laruelle M Carson RE Hannestad J Huang Y J Nucl Med 2016 free It is used to study the brain changes associated with several diseases including Alzheimer's disease, 10.2967/jnumed.118.223867 31101744 In vivo synaptic density imaging with 11C-UCB-J detects treatment effects of saracatinib (AZD0530) in a mouse model of Alzheimer's disease Journal of Nuclear Medicine 1780–1786 2019 Toyonaga Takuya Smith Levi M. Finnema Sjoerd J. Gallezot Jean-Dominique Naganawa Mika Bini Jason Mulnix Tim Cai Zhengxin Ropchan Jim Huang Yiyun Strittmatter Stephen M. Carson Richard E. 60 12 6894376 free 10.1186/s13024-019-0325-5 31174557 6555939 Neuroimaging Biomarkers for Alzheimer's Disease Molecular Neurodegeneration 14 1 21 2019 Márquez Freddie Yassa Michael A. free schizophrenia,Onwordi Ellis Chika Halff Els F. Whitehurst Thomas Mansur Ayla Cotel Marie-Caroline Wells Lisa Creeney Hannah Bonsall David Rogdaki Maria Shatalina Ekaterina Reis Marques Tiago Rabiner Eugenii A. Gunn Roger N. Natesan Sridhar Vernon Anthony C. Howes Oliver D. Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats Nature Communications 14 January 2020 11 1 246 10.1038/s41467-019-14122-0 31937764 6959348 2020NatCo..11..246O en 2041-1723 free 10.1016/j.biopsych.2017.02.688 962. In-vivo Evidence of Decreased Synaptic Density in Schizophrenia: A [11C]UCB-J PET Imaging Study Biological Psychiatry 81 10 S389 2017 Radhakrishnan Rajiv Skosnik Patrick Finnema Sjoerd Rotolo Renee Forselius-Bielen Kimberlee Creatura Gina Nabulsi Nabeel Carson Richard d׳Souza Deepak 54259458 and depression. 10.1038/s41467-019-09562-7 free 30948709 6449365 Lower synaptic density is associated with depression severity and network alterations Nature Communications 10 1 1529 2019 Holmes Sophie E. Scheinost Dustin Finnema Sjoerd J. Naganawa Mika Davis Margaret T. Dellagioia Nicole Nabulsi Nabeel Matuskey David Angarita Gustavo A. Pietrzak Robert H. Duman Ronald S. Sanacora Gerard Krystal John H. Carson Richard E. Esterlis Irina 2019NatCo..10.1529H References Category:PET radiotracers Category:Disubstituted pyridines Category:Pyrrolidones Category:Trifluorophenyl compounds Category:Pyridines