2-Polyprenyl-6-hydroxyphenol methylase

Class of enzymes 2-polyprenyl-6-hydroxyphenol methylase 2.1.1.222 2-polyprenyl-6-hydroxyphenol methylase (2.1.1.222, ubiG (gene), ubiG methyltransferase, 2-octaprenyl-6-hydroxyphenol methylase) is an enzyme with systematic name S-adenosyl-L-methionine:3-(all-trans-polyprenyl)benzene-1,2-diol 2-O-methyltransferase. Poon WW, Barkovich RJ, Hsu AY, Frankel A, Lee PT, Shepherd JN, Myles DC, Clarke CF Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis The Journal of Biological Chemistry 274 31 21665–72 July 1999 10419476 10.1074/jbc.274.31.21665 free Hsu AY, Poon WW, Shepherd JA, Myles DC, Clarke CF Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis Biochemistry 35 30 9797–806 July 1996 8703953 10.1021/bi9602932 This enzyme catalyses the following chemical reaction S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol UbiG catalyses both methylation steps in ubiquinone biosynthesis in Escherichia coli. References External links 2-polyprenyl-6-hydroxyphenyl+methylase Biology no Category:EC 2.1.1