2-Ketoarginine methyltransferase

Class of enzymes vanc 6 2-Ketoarginine methyltransferase 2.1.1.243 2-Ketoarginine methyltransferase (2.1.1.243, mrsA (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:5-carbamimidamido-2-oxopentanoate S-methyltransferase.2.1.1.243 This enzyme catalyses the following chemical reaction 65% Q27103511 5-guanidino-2-oxopentanoic acid 3.5 + SAM class=skin-invert-image (3R)-5-guanidino-3-methyl-2-oxopentanoic acid + SAH This is a methylation reaction in which the methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from Pseudomonas syringae. It is involved in production of the rare amino acid 3-methylarginine. Braun SD, Hofmann J, Wensing A, Ullrich MS, Weingart H, Völksch B, Spiteller D Identification of the biosynthetic gene cluster for 3-methylarginine, a toxin produced by Pseudomonas syringae pv. syringae 22d/93 Applied and Environmental Microbiology 76 8 2500–2508 April 2010 20190091 10.1128/aem.00666-09 2849186 Other organisms use it to incorporate that amino acid into arginomycin. Feng J, Wu J, Gao J, Xia Z, Deng Z, He X Biosynthesis of the β-methylarginine residue of peptidyl nucleoside arginomycin in Streptomyces arginensis NRRL 15941 Applied and Environmental Microbiology 80 16 5021–5027 August 2014 24907335 10.1128/AEM.01172-14 4135772 References External links 2-ketoarginine+methyltransferase Biology no Category:EC 2.1.1