(S)-DCPT

vanc 6 (S)-DCPT structure.svg skin-invert-image 250px Serotonin 5-HT1B receptor agonist None 156011291 129494222 4637900 (2S)-5-(2-chlorophenyl)-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine 22 28 1 1 CCCN(CCC)[C@H]1CCC2=C(C1)C=CC=C2C3=CC=CC=C3Cl 1S/C22H28ClN/c1-3-14-24(15-4-2)18-12-13-19-17(16-18)8-7-10-20(19)21-9-5-6-11-22(21)23/h5-11,18H,3-4,12-16H2,1-2H3/t18-/m0/s1 QSQZCAQYYCNBSR-SFHVURJKSA-N (S)-DCPT is an experimental drug of the 2-aminotetralin family, related to the selective serotonin 5-HT1A receptor agonist 8-OH-DPAT. However, (S)-DPCT instead acts as a selective agonist for the serotonin 5-HT1B receptor, with moderate selectivity over 5-HT1D and good selectivity over 5-HT1A, 5-HT7, and other serotonin receptors. Perry CK, Casey AB, Felsing DE, Vemula R, Zaka M, Herrington NB, Cui M, Kellogg GE, Canal CE, Booth RG Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT1A and 5-HT7 G protein-coupled receptor affinity, 3D-QSAR and molecular modeling Bioorganic & Medicinal Chemistry 28 3 115262 February 2020 31882369 10.1016/j.bmc.2019.115262 free McGlynn R Insights into the molecular pharmacology of novel aminotetralins and known drug candidates at serotonin 5-HT1-type receptors. PhD Northeastern University 2023 10.17760/D20537503 free See also Substituted 2-aminotetralin UH-232 UH-301 References Category:5-HT1B agonists Category:2-Aminotetralins Category:2-Chlorophenyl compounds Category:Dipropylamino compounds