(RS)-MCPG

Chemical compound (RS)-MCPG is a phenylglycine derivative and a non-selective antagonist of group I and II metabotropic glutamate receptors (mGluRs). It has been used in long-term potentiation (LTP) as well as long-term depression (LTD) research and proved that certain LTP and LTD pathways depend on mGluRs. Bortolotto ZA, Bashir ZI, Davies CH, Collingridge GL A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation Nature 368 6473 740–3 April 1994 8152485 10.1038/368740a0 1994Natur.368..740B 4255573 Otani S, Connor JA Requirement of rapid Ca2+ entry and synaptic activation of metabotropic glutamate receptors for the induction of long-term depression in adult rat hippocampus The Journal of Physiology 511 (Pt 3) 3 761–70 September 1998 9714858 2231146 10.1111/j.1469-7793.1998.761bg.x Its full chemical name is (RS)-α-methyl-4-carboxyphenylglycine. It appears as a white solid and its molecular weight is 209.2 Da. Its molecular formula is C10H11NO4. (RS)-MCPG https://www.hellobio.com/rs-mcpg.html Hello Bio References Category:Metabotropic glutamate receptor antagonists