(citrate (pro-3S)-lyase) ligase

Class of enzymes [Citrate (pro-3S)-lyase] ligase 6.2.1.22 52660-22-7 0008771 In enzymology, a [citrate (pro-3S)-lyase] ligase (6.2.1.22) is an enzyme that catalyzes the chemical reaction ATP + acetate + citrate (pro-3S)-lyase(thiol form) AMP + diphosphate + citrate (pro-3S)-lyase(acetyl form) The 3 substrates of this enzyme are ATP, acetate, and citrate (pro-3S)-lyase(thiol form), whereas its 3 products are AMP, diphosphate, and citrate (pro-3S)-lyase(acetyl form). This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acetate:citrate (pro-3S)-lyase(thiol-form) ligase (AMP-forming). Other names in common use include citrate lyase ligase, citrate lyase synthetase, acetate: SH-acyl-carrier-protein enzyme ligase (AMP), acetate:HS-citrate lyase ligase, and acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming). This enzyme participates in two-component system - general. References 1 Antranikian G, Gottschalk G 1982 Copurification of citrate lyase and citrate lyase ligase from Rhodopseudomonas gelatinosa and subsequent separation of the two enzymes Eur. J. Biochem. 126 43–7 7128585 10.1111/j.1432-1033.1982.tb06743.x 1 Antranikian G, Herzberg C, Gottschalk G 1985 Covalent modification of citrate lyase ligase from Clostridium sphenoides by phosphorylation/dephosphorylation Eur. J. Biochem. 153 413–20 3935436 10.1111/j.1432-1033.1985.tb09318.x 2 free Quentmeier A, Antranikian G 1985 Characterization of citrate lyase from Clostridium sporosphaeroides Arch. Microbiol. 141 85–90 3994485 10.1007/BF00446745 1 1985ArMic.141...85Q 32612466 Schmellenkamp H, Eggerer H 1974 Mechanism of enzymic acetylation of des-acetyl citrate lyase Proc. Natl. Acad. Sci. U.S.A. 71 1987–91 4365579 10.1073/pnas.71.5.1987 5 388369 1974PNAS...71.1987S free Biology no Category:EC 6.2.1 Category:Enzymes of unknown structure