1-Naphthylmethcathinone

vanc 6 1-Naphthylmethcathinone.svg skin-invert-image 215px Serotonin–norepinephrine–dopamine releasing agent 854674-62-7 112704364 72080032 DM7M36B5BS AMAPN 2-(methylamino)-1-naphthalen-1-ylpropan-1-one 14 15 1 1 CC(C(=O)C1=CC=CC2=CC=CC=C21)NC 1S/C14H15NO/c1-10(15-2)14(16)13-9-5-7-11-6-3-4-8-12(11)13/h3-10,15H,1-2H3 QIACKSHQBOUATI-UHFFFAOYSA-N 1-Naphthylmethcathinone (AMAPN) is a monoamine releasing agent of the cathinone and naphthylaminopropane families. Blough BE, Decker AM, Landavazo A, Namjoshi OA, Partilla JS, Baumann MH, Rothman RB The dopamine, serotonin and norepinephrine releasing activities of a series of methcathinone analogs in male rat brain synaptosomes Psychopharmacology (Berl) 236 3 915–924 March 2019 30341459 6475490 10.1007/s00213-018-5063-9 Yadav BJ Understanding Structure–Activity Relationship of Synthetic Cathinones (Bath Salts) Utilizing Methylphenidate VCU Scholars Compass 16 July 2019 10.25772/MJQW-8C64 https://scholarscompass.vcu.edu/etd/5955/ 24 November 2024 It is an analogue of methcathinone in which the phenyl ring has been replaced with a 1-naphthalene ring. The drug acts as a potent serotonin–norepinephrine–dopamine releasing agent (SNDRA). Its EC50 half-maximal effective concentration values for induction of monoamine release are 21.6nM for serotonin and 55.2nM for dopamine, whereas the EC50 half-maximal effective concentration for norepinephrine was not reported. However, AMAPN induced 92% release of norepinephrine at a concentration of 10,000nM, indicating that it is an effective norepinephrine releaser as well. See also 1-Naphthylaminopropane (1-NAP) 2-Naphthylmethcathinone (BMAPN) 2,3-Methylenedioxyamphetamine (2,3-MDA) 2,3-Methylenedioxymethamphetamine (2,3-MDMA) References Category:Cathinones Category:Designer drugs Category:Methamphetamines Category:1-Naphthyl compounds Category:Serotonin-norepinephrine-dopamine releasing agents