16S rRNA (cytidine1409-2'-O)-methyltransferase

Class of enzymes 16S rRNA (cytidine1409-2'-O)-methyltransferase 2.1.1.227 16S rRNA (cytidine1409-2'-O)-methyltransferase (2.1.1.227, TlyA) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytidine1409-2'-O)-methyltransferase. Johansen SK, Maus CE, Plikaytis BB, Douthwaite S Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs Molecular Cell 23 2 173–82 July 2006 16857584 10.1016/j.molcel.2006.05.044 free Maus CE, Plikaytis BB, Shinnick TM Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis Antimicrobial Agents and Chemotherapy 49 2 571–7 February 2005 15673735 547314 10.1128/AAC.49.2.571-577.2005 This enzyme catalyses the following chemical reaction S-adenosyl-L-methionine + cytidine1409 in 16S rRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA The bifunctional enzyme from Mycobacterium tuberculosis. References External links 16S+rRNA+(cytidine1409-2'-O)-methyltransferase Biology no Category:EC 2.1.1