2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

Class of enzymes 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase (1.1.1.312, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, LigC, ProD) is an enzyme with systematic name 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase. Maruyama K, Ariga N, Tsuda M, Deguchi K Purification and properties of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase Journal of Biochemistry 83 4 1125–34 April 1978 10.1093/oxfordjournals.jbchem.a132002 26671 free Maruyama K Isolation and identification of the reaction product of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase Journal of Biochemistry 86 6 1671–7 December 1979 10.1093/oxfordjournals.jbchem.a132687 528534 free Maruyama K Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase Journal of Biochemistry 93 2 557–65 February 1983 10.1093/oxfordjournals.jbchem.a134210 6841353 free Masai E, Momose K, Hara H, Nishikawa S, Katayama Y, Fukuda M Genetic and biochemical characterization of 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase and its role in the protocatechuate 4,5-cleavage pathway in Sphingomonas paucimobilis SYK-6 Journal of Bacteriology 182 23 6651–8 December 2000 11073908 111406 10.1128/jb.182.23.6651-6658.2000 This enzyme catalyses the following chemical reaction:1.1.1.312 60% Q27131524 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ reversible H+ H+ Q27102682 2-oxo-2H-pyran-4,6-dicarboxylic acid 1.2 + NADPH Unsubstituted aliphatic or aromatic aldehydes or glucose cannot serve as substrate of this enzyme. References External links 2-hydroxy-4-carboxymuconate+semialdehyde+hemiacetal+dehydrogenase Biology no Category:EC 1.1.1