1,8-Cineole 2-exo-monooxygenase

Class of enzymes 1,8-Cineole 2-exo-monooxygenase 1.14.14.56 1,8-Cineole 2-exo-monooxygenase (1.14.14.56, CYP3A4) is an enzyme with systematic name 1,8-cineole,NADPH:oxygen oxidoreductase (2-exo-hydroxylating). Miyazawa M, Shindo M, Shimada T Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes Drug Metabolism and Disposition 29 2 200–5 February 2001 11159812 Miyazawa M, Shindo M, Shimada T Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes Xenobiotica; The Fate of Foreign Compounds in Biological Systems 31 10 713–23 October 2001 11695850 10.1080/00498250110065595 This enzyme catalyses the following chemical reaction 50% eucalyptol + NADPH + H+ O2 H2O Q27101824 2-exo-hydroxy-1,8-cineole 1.2 + NADP+ The four substrates of this enzyme are eucalyptol, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are 2-exo-hydroxy-1,8-cineole, oxidised NADP+, and water. It is a cytochrome P450 protein containing heme.1.14.14.56 Miyazawa M, Shindo M Biotransformation of 1,8-cineole by human liver microsomes Natural Product Letters 15 1 49–53 2001 11547423 10.1080/10575630108041257 References External links 1,8-cineole+2-exo-monooxygenase Biology no Category:EC 1.14.14