(acyl-carrier-protein) phosphodiesterase

Enzyme [acyl-carrier-protein] phosphodiesterase 3.1.4.14 37288-21-4 0008770 The enzyme [acyl-carrier-protein] phosphodiesterase (EC 3.1.4.14) catalyzes the reaction holo-[acyl-carrier-protein] + H2O 4-phosphopantetheine + apo-[acyl-carrier-protein] This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name is holo-[acyl-carrier-protein] 4-pantetheine-phosphohydrolase. Other names in common use include ACP hydrolyase, ACP phosphodiesterase, AcpH, and [acyl-carrier-protein] 4-pantetheine-phosphohydrolase. This enzyme participates in pantothenate and CoA biosynthesis. ACP hydrolyase and ACP hydrolyase homologues are related to the hydrolyase domain of the bacterial protein SpoT. AcpH hydrolyzes the link between acyl carrier protein's serine-36 side chain and 4'-phosphopanthetheine. Jacob Thomas Daniel J. Rigden John E. Cronan 2007 Acyl carrier protein phosphodiesterase (AcpH) of Eschirichia coli is a non-canonical member of the HD phosphatase/phosphodiesterase family Biochemistry 46 1 Structural studies As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T5B and 1TIK. References 30em Sobhy C 1979 Regulation of fatty acid synthetase activity. The 4-phosphopantetheine hydrolase of rat liver J. Biol. Chem. 254 8561–6 224058 17 10.1016/S0021-9258(19)86929-6 free Vagelos PR, Larrabes AR 1967 Acyl carrier protein. IX. Acyl carrier protein hydrolase J. Biol. Chem. 242 1776–81 4290442 8 10.1016/S0021-9258(18)96069-2 free Thomas J, Cronan JE 2005 The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization J. Biol. Chem. 280 34675–83 16107329 10.1074/jbc.M505736200 41 free Biology no Category:EC 3.1.4 Category:Enzymes of known structure