2-iminoacetate synthase

Class of enzymes 2-iminoacetate synthase 4.1.99.19 2-iminoacetate synthase (4.1.99.19, thiH (gene)) is an enzyme with systematic name L-tyrosine 4-methylphenol-lyase (2-iminoacetate-forming). Leonardi R, Fairhurst SA, Kriek M, Lowe DJ, Roach PL Thiamine biosynthesis in Escherichia coli: isolation and initial characterisation of the ThiGH complex FEBS Letters 539 1–3 95–9 March 2003 12650933 10.1016/s0014-5793(03)00204-7 2003FEBSL.539...95L free Kriek M, Martins F, Challand MR, Croft A, Roach PL Thiamine biosynthesis in Escherichia coli: identification of the intermediate and by-product derived from tyrosine Angewandte Chemie 46 48 9223–6 2007 17969213 10.1002/anie.200702554 2007ACIE...46.9223K https://zenodo.org/record/2642082 Kriek M, Martins F, Leonardi R, Fairhurst SA, Lowe DJ, Roach PL Thiazole synthase from Escherichia coli: an investigation of the substrates and purified proteins required for activity in vitro The Journal of Biological Chemistry 282 24 17413–23 June 2007 17403671 10.1074/jbc.M700782200 free This enzyme catalyses the following chemical reaction L-tyrosine + S-adenosyl-L-methionine + reduced acceptor 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+ This enzyme binds a 4Fe-4S cluster. References External links 2-iminoacetate+synthase Biology no Category:EC 4.1.99