2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase

Class of enzymes 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase 1.1.1.126 37250-55-8 0047000 In enzymology, a 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase (1.1.1.126) is an enzyme that catalyzes the chemical reaction 50% Q27102179 2-dehydro-3-deoxy-D-gluconic acid 1.1 + NADP+ reversible H+ H+ Q27098153 (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoic acid + NADPH The two substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconic acid and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoic acid, reduced NADPH, and a proton.1.1.1.126 Preiss J, Ashwell G Alginic acid metabolism in bacteria. II. The enzymatic reduction of 4-deoxy-L-erythro-5-hexoseulose uronic acid to 2-keto-3-deoxy-D-gluconic acid The Journal of Biological Chemistry 237 317–21 February 1962 2 10.1016/S0021-9258(18)93921-9 free 14488585 This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase. Other names in common use include 2-keto-3-deoxy-D-gluconate dehydrogenase, and 2-keto-3-deoxygluconate dehydrogenase. References Biology no Category:EC 1.1.1 Category:NADPH-dependent enzymes Category:Enzymes of known structure