2-oxoisovalerate dehydrogenase (acylating)

Class of enzymes 2-oxoisovalerate dehydrogenase (acylating) 1.2.1.25 37211-61-3 0047101 In enzymology, 2-oxoisovalerate dehydrogenase (acylating) (1.2.1.25) is an enzyme that catalyzes the chemical reaction 50% α-Ketoisovaleric acid + CoA + NAD+ reversible CO2 + H+ CO2 + H+ class=skin-invert-image Isobutyryl-CoA + NADH The three substrates of this enzyme are α-ketoisovaleric acid, coenzyme A (CoA), and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are isobutyryl-CoA, carbon dioxide, reduced NADH and a proton.1.2.1.25Namba Y, Yoshizawa K, Ejima A, Hayashi T, Kaneda T 1969 Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched chain alpha-keto acid dehydrogenase. I. Purification and properties of the enzyme from Bacillus subtilis J. Biol. Chem. 244 4437–47 4308861 16 10.1016/S0021-9258(18)94337-1 free This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating). Other names in common use include 2-oxoisovalerate dehydrogenase, and alpha-ketoisovalerate dehydrogenase. This enzyme participates in valine, leucine and isoleucine degradation. References Biology no Category:EC 1.2.1 Category:NADH-dependent enzymes Category:Enzymes of unknown structure