(pyruvate dehydrogenase (acetyl-transferring))-phosphatase

Class of enzymes [pyruvate dehydrogenase (lipoamide)] phosphatase 3.1.3.43 9073-70-5 0004741 The enzyme [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (EC 3.1.3.43) catalyzes the reaction [pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O [pyruvate dehydrogenase (acetyl-transferring)] + phosphate This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is [pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase. Other names in common use include pyruvate dehydrogenase phosphatase, phosphopyruvate dehydrogenase phosphatase, [pyruvate dehydrogenase (lipoamide)]-phosphatase, and [pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase. Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PNQ. References 1 Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ 1972 α-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart Arch. Biochem. Biophys. 148 327–42 4401694 10.1016/0003-9861(72)90151-8 2 Reed LJ, Damuni Z, Merryfield ML 1985 Regulation of mammalian pyruvate and branched-chain α-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation Curr. Top. Cell. Regul. Current Topics in Cellular Regulation 27 41–9 10.1016/b978-0-12-152827-0.50011-6 3004826 Biology no Category:EC 3.1.3 Category:Enzymes of known structure