(S)-methylmalonyl-CoA hydrolase

Class of enzymes (S)-methylmalonyl-CoA hydrolase 3.1.2.17 87928-03-8 0047511 The enzyme (S)-methylmalonyl-CoA hydrolase (EC 3.1.2.17) catalyzes the reaction 70% (S)-methylmalonyl-CoA H2O class=skin-invert-image coenzyme A + methylmalonic acid 2 The enzyme characterised from liver hydrolyses (S)-methylmalonyl-CoA to coenzyme A and methylmalonic acid, which forms the thioester in the starting material.Kovachy R. J. Copley S. D. Allen R. H. Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme a hydrolase Journal of Biological Chemistry 1983 258 18 11415–11421 10.1016/S0021-9258(17)44433-4 free 6885824 Kovachy Robin J. Stabler Sally P. Allen Robert H. Branched-Chain Amino Acids D-methylmalonyl-CoA hydrolase Methods in Enzymology 1988 166 393–400 10.1016/S0076-6879(88)66051-4 3071714 978-0-12-182067-1 Schomburg Dietmar Stephan Dörte Enzyme Handbook 15 (S)-Methylmalonyl-CoA hydrolase 1998 79–81 10.1007/978-3-642-58948-5_19 978-3-540-64116-2 The starting material is produced from propionyl-CoA, a breakdown product of some amino acids, and an increase of methylmalonic acid is a marker of vitamin B12 deficiency as methylmalonyl-CoA is converted to succinyl-CoA by an enzyme using the vitamin as a cofactor.Dhar Indu Lysne Vegard Ulvik Arve Svingen Gard F. T. Pedersen Eva R. Bjørnestad Espen Ø. Olsen Thomas Borsholm Robert Laupsa-Borge Johnny Ueland Per M. Tell Grethe S. Berge Rolf K. Mellgren Gunnar Bønaa Kaare H. Nygård Ottar K. 3 Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2-cohort study Journal of Internal Medicine 2023 293 4 508–519 10.1111/joim.13610 36682040 11250/3117991 free This enzyme is a hydrolase, specifically one acting on thioester bonds. The systematic name of this enzyme class is (S)-methylmalonyl-CoA hydrolase. This enzyme is also called D-methylmalonyl-coenzyme A hydrolase.3.1.2.17 References Biology no Category:EC 3.1.2 Category:Enzymes of unknown structure