(R)-3-Nitrobiphenyline

Drug 456494074 (R)-2-[1-(3'-Nitrobiphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole (R)-3-Nitrobiphenyline.svg skin-invert-image 170 (R)-3-Nitrobiphenyline a682611 correct ?? 945618-95-1 correct FDA PQ8VMX7SUU correct EBI 242693 16757089 correct chemspider 23288036 17 17 3 3 c2ccc([N](=O)=O)cc2-c1ccccc1OC(C)C3=NCCN3 correct chemspider 1S/C17H17N3O3/c1-12(17-18-9-10-19-17)23-16-8-3-2-7-15(16)13-5-4-6-14(11-13)20(21)22/h2-8,11-12H,9-10H2,1H3,(H,18,19)/t12-/m1/s1 correct chemspider NMSAVNXFCXMJJY-GFCCVEGCSA-N (R)-3-Nitrobiphenyline is a drug. As an α2-adrenergic agonist, it activates α2 adrenergic receptors, which respond to the hormones adrenaline (also known as epinephrine) and noradrenaline (norepinephrine). It is selective for the α2C subtype, as well as being a weak antagonist at the α2A and α2B subtypes. It has been used in scientific research to characterize the binding and functional properties of the α2C subtype. Crassous PA, Cardinaletti C, Carrieri A, Bruni B, Di Vaira M, Gentili F, Ghelfi F, Giannella M, Paris H, Piergentili A, Quaglia W, Schaak S, Vesprini C, Pigini M 6 Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist Journal of Medicinal Chemistry 50 16 3964–3968 August 2007 17630725 10.1021/jm061487a Del Bello F, Mattioli L, Ghelfi F, Giannella M, Piergentili A, Quaglia W, Cardinaletti C, Perfumi M, Thomas RJ, Zanelli U, Marchioro C, Dal Cin M, Pigini M 6 Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence Journal of Medicinal Chemistry 53 21 7825–7835 November 2010 20925410 10.1021/jm100977d References Category:Alpha2-adrenergic agonists Category:Biphenyls Category:Imidazolines Category:3-Nitrophenyl compounds Category:Phenol ethers