2-Me-DET

Chemical compound 2-Me-DET structure.svg skin-invert-image 200px 2-Me-DET 3D.png bg-transparent 225px Oral Psychoactive drug; Serotonergic psychedelic; Hallucinogen None 6–8 hours 26628-88-6 correct FDA SSF4F77CV3 33561 30962 2-Methyl-DET; 2-Methyl-N,N-diethyltryptamine N,N-diethyl-2-(2-methyl-1H-indol-3-yl)ethanamine 15 22 2 CCN(CC)CCc1c(C)[nH]c2ccccc12 1S/C15H22N2/c1-4-17(5-2)11-10-13-12(3)16-15-9-7-6-8-14(13)15/h6-9,16H,4-5,10-11H2,1-3H3 VVUATPWGKMGHGM-UHFFFAOYSA-N 2-Me-DET, or 2-methyl-DET, also known as 2-methyl-N,N-diethyltryptamine, is a psychedelic drug of the tryptamine family. It is the 2-methyl derivative of diethyltryptamine (DET). The drug is taken orally. Use and effects In his book TiHKAL (Tryptamines I Have Known and Loved), Alexander Shulgin lists 2-Me-DET's dose as 80 to 120mg orally and its duration as 6 to 8hours. The effects of 2-Me-DET have been reported to include a vague unreal feeling, clouding and slowing of thoughts, DiPT-like sound distortion including higher pitches of music sounding muffled and tones shifting to a lower frequency, and stomach ache. Interactions Psychedelic drug#Interactions Trip killer#Serotonergic psychedelic antidotes Pharmacology Pharmacodynamics 2-Me-DET is a serotonin receptor agonist in the rat uterus and stomach strip, with similar potency as dimethyltryptamine (DMT) and diethyltryptamine (DET) but profoundly greater potency than 2-methyl-DMT. Barlow RB, Khan I Actions of some analogues of tryptamine on the isolated rat uterus and on the isolated rat fundus strip preparations Br J Pharmacol Chemother 14 1 99–107 March 1959 13651585 1481812 10.1111/j.1476-5381.1959.tb00934.x Chemistry Synthesis The chemical synthesis of 2-Me-DET has been described. Analogues Analogues of 2-Me-DET include 2-methyltryptamine (2-MT; 2-Me-T), 2-methyl-DMT (2-Me-DMT; 2,N,N-TMT), 2-methyl-5-MeO-DMT (5-MeO-2,N,N-TMT), and 2-methyl-AMT (2-Me-AMT; 2,α-DMT). History 2-Me-DET was first described in the scientific literature by R. B. Barlow and I. Khan in 1959. Barlow RB, Khan I Actions of some analogues of tryptamine on the isolated rat uterus and on the isolated rat fundus strip preparations Br J Pharmacol Chemother 14 1 99–107 March 1959 13651585 1481812 10.1111/j.1476-5381.1959.tb00934.x Subsequently, it was described in greater detail by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved). See also Substituted tryptamine References External links 2-Methyl-DET - Isomer Design 2-Me-DET - TiHKAL - Erowid 2-Me-DET - TiHKAL - Isomer Design Category:2-Alkyltryptamines Category:N,N-Dialkyltryptamines Category:Diethylamino compounds Category:Psychedelic tryptamines Category:Serotonin receptor modulators Category:TiHKAL