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1T-LSD
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Chemical compound
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1T-LSD.svg skin-invert-image 200px 1T-LSD 3D.png bg-transparent 250px Oral Serotonergic psychedelic; Hallucinogen correct CAS 3028949-85-8 170763788 129341136 1-(Thiophene-2-carbonyl)-LSD; SYN-L-021 (6aR,9R)-N,N-diethyl-7-methyl-4-(thiophen-2-yl)methanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide 25 27 3 2 1 O=C(n1cc2C[C@@H]3C(=C[C@H](CN3C)C(=O)N(CC)CC)c3cccc1c32)c1cccs1
1T-LSD, also known as 1-(thiophene-2-carbonyl)-LSD or as SYN-L-021, is an acylated derivative of lysergic acid diethylamide (LSD), which has been sold as a designer drug.1T-LSD АИПСИН 21 August 2023 https://aipsin.com/newsubstance/1188/ ru 1 January 20261T-LSD АИПСИН https://aipsin.com/newsubstance/1750/ ru 1 January 2026 It was first identified in Japan in 2023 on blotter paper misrepresented as containing 1D-LSD, but which on analysis was determined to contain 1T-LSD instead. Okada Y, Ueno K, Nishiwaki N, Nishimura T, Segawa H, Yamamuro T, Kuwayama K, Tsujikawa K, Kanamori T, Iwata YT Identification of 1-(thiophene-2-carbonyl)-LSD from blotter paper falsely labeled "1D-LSD" Forensic Toxicology 42 1 July 2023 93–101 37421500 10.1007/s11419-023-00668-8 259374662 It was also detected in Germany around the same time. https://www.euda.europa.eu/sites/default/files/pdf/31883_en.pdf?606797 New psychoactive substances - the current situation in Europe European Drug Report European Union Drugs Agency (EUDA) 2024
Use and effects
LSD#Uses LSD#Effects
A 150μg dose of 1T-LSD is said to be equivalent to 100μg LSD.1T-LSD АИПСИН https://aipsin.com/newsubstance/2008/ ru 30 July 2026 Doses of 87 to 100μg 1T-LSD have been encountered in blotter tabs. It has also been encountered in tablets. As a prodrug of LSD, the drug is said to produce psychoactive effects comparable to LSD. There are no data on how delayed the onset of 1T-LSD may be compared to LSD.
Interactions
Psychedelic drug#Interactions Trip killer#Serotonergic psychedelic antidotes
Chemistry
Analogues
Analogues of 1T-LSD include ALD-52 (1A-LSD), 1P-LSD, 1B-LSD, 1V-LSD, 1DD-LSD, and 1T-AL-LAD, among others.
Society and culture
Legal status
Canada
1T-LSD is not a controlled substance in Canada as of 2025.Controlled Drugs and Substances Act Department of Justice Canada https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 19 January 2026
United States
1T-LSD is not an explicitly controlled substance in the United States. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) January 2026 U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division United States https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.
See also
Substituted lysergamide
Lizard Labs
References
External links
1T-LSD - Isomer Design
Category:5-HT2A agonists
Category:Designer prodrugs
Category:Diethylamides
Category:Lizard Labs
Category:Psychedelic lysergamides
Category:Serotonin receptor agonists
Category:Thiophenes